Environmental Estrogen-like Substances Enhances 1-Methyl-4-Phenylpyridinium Ion-Induced Hydroxyl Radical Generation in Rat Striatum
نویسندگان
چکیده
Toshio Obata1, Michiko Nakashima2 1Faculty of Health Sciences, Osaka Aoyama University, School of Nursing Niina, Mino City, Japan. 2Department of Nursing, School of Health Siences, Asahi University, 1851 Hozumi Mizuho City Gifu, Japan. Corresponding Author: Toshio Obata, Osaka Aoyama University, Faculty of Health Sciences, School of Nursing Niina, Mino City, Japan.Ankara, Turkey. Tel: +81-72-737-6754; Email: [email protected]
منابع مشابه
Comparative toxicity and antioxidant activity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and its monoamine oxidase B-generated metabolites in isolated hepatocytes and liver microsomes.
MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is converted by monoamine oxidase B to its putative toxic metabolite MPP+ (1-methyl-4-phenylpyridinium ion) via MPDP+ (1-methyl-4-phenyl-2,3-dihydropyridinium ion). Both the parent compound and these two major metabolites were toxic to isolated rat hepatocytes with MPDP+ being the most toxic and MPP+ the least effective. MPP+ produced a slight...
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